Open AccessNext-generation sequencing revealed synchronous double primary lung squamous carcinoma: a case report
Author(s) -
Desong Yang,
KaiWen Huang,
Min Su,
Tingting Wang,
Sisi Liu,
Yang Xu,
Wenxiang Wang
Publication year - 2021
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/03000605211018575
Subject(s) - medicine , lung cancer , lung , hepatocellular carcinoma , carcinoma , pathology , histology , oncology , squamous carcinoma , primary tumor , cancer , metastasis
Synchronous double primary lung squamous carcinoma (sDPLSCC) is rare and difficult to distinguish from metastatic disease, histopathologically. Owing to the heterogeneity of cancer, it is also difficult to select the optimal therapeutic strategy for patients with multiple primary lung cancer (MPLC). The present study reports a rare case of a 61-year-old male patient with sDPLSCC diagnosed using histology and genetic profiling. LSCC-related driver mutations were detected in this patient, and we reported the TP53 c.475G>C mutation, which has been detected in both breast cancer and hepatocellular carcinoma, but not previously in lung squamous carcinoma. Our findings provide further evidence supporting the necessity of genetic testing for primary tumor diagnosis.