Open AccessExpression of delta-like 4 (Drosophila) and vascular endothelial growth factor A in colon cancer and association with tumour angiogenesis
Author(s) -
Yongbin Zheng,
ZhiNan Hao,
Yu Ding,
Qiushuang Wang,
Shengbo Li,
Gaochun Xiao,
Haiping Luo,
Qiang Shi,
Shilun Tong
Publication year - 2015
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513507388
Subject(s) - angiogenesis , colorectal cancer , medicine , adenoma , vascular endothelial growth factor , cd34 , vascular endothelial growth factor a , cancer research , pathology , metastasis , immunohistochemistry , notch signaling pathway , cancer , oncology , biology , vegf receptors , receptor , stem cell , genetics
Objective Angiogenesis depends on interaction between a variety of promoting and inhibiting factors, and is known to involve vascular endothelial growth factor (VEGF) A and the Notch signaling pathway. The present study investigated the expression of Notch ligand delta-like ( DLL) 4 (Drosophila), and VEGFA in colon cancer and colorectal adenoma tissue, and the association with tumour angiogenesis.Methods Protein level DLL4, VEGFA and CD34 molecule ( CD34) expression was detected immunohistochemically in tissue sections from patients with colon cancer and colorectal adenoma.Results Out of 80 cases (35 with colon cancer, 45 with colorectal adenoma) DLL4 and VEGFA expression was closely related to tumour diameter, clinical stage, histological grade and lymph node metastasis. DLL4 expression was significantly higher in colon cancer tissue than colorectal adenoma tissue.Conclusion High levels of DLL4 expression were closely related to metastasis and prognosis in patients with colon cancer. The results of the present study support the conclusion that prognosis of colon cancer is significantly correlated with angiogenesis.