Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke | Zendy

Oana Dumitrașcu | Zendy; Jessica Lamb | Zendy; Patrick D. Lyden | Zendy

Open Access

Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke

Author(s) -

Oana Dumitrașcu,

Jessica Lamb,

Patrick D. Lyden

Publication year - 2016

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1177/0271678x16645112

Subject(s) - hypothermia , medicine , stroke (engine) , clinical trial , therapeutic effect , ischemia , meta analysis , ischemic stroke , brain ischemia , intensive care medicine , anesthesia , mechanical engineering , engineering

Therapeutic hypothermia is the most potent neuroprotectant for experimental cerebral ischemia, illustrated in a 2007 meta-analysis published in this journal. To address recent therapeutic nihilism, we systematically reviewed recent experimental literature. Quality scoring showed considerable improvement in study design. Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic stroke re-emphasize that therapeutic hypothermia is potently effective, justifying further development in larger human clinical trials.

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