Open AccessContrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement
Author(s) -
Josephine Palandri,
Sharon L. Smith,
David J. Heal,
S Wonnacott,
Christopher Bailey
Publication year - 2021
Publication title -
journal of psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.333
H-Index - 114
eISSN - 1461-7285
pISSN - 0269-8811
DOI - 10.1177/0269881121991570
Subject(s) - methyllycaconitine , conditioned place preference , nicotinic agonist , pharmacology , heroin , mecamylamine , psychology , opioid , nicotinic acetylcholine receptor , self administration , morphine , medicine , drug , receptor
α7 Nicotinic acetylcholine receptors are implicated in the reinstatement of drug-seeking, an important component of relapse. We showed previously that the α7 nicotinic acetylcholine receptor antagonist, methyllycaconitine, specifically attenuated morphine-primed reinstatement of conditioned place preference in rodents and this effect was mediated in the ventral hippocampus.