Prevalence of Persistent Olfactory Disorders in Patients With COVID‐19: A Psychophysical Case‐Control Study With 1‐Year Follow‐up | Zendy

Vaira Luigi Angelo | Zendy; Salzano Giovanni | Zendy; Le Bon Serge Daniel | Zendy; Maglio Angelantonio | Zendy; Petrocelli Marzia | Zendy; Steffens Younes | Zendy; Ligas Enrica | Zendy; Maglitto Fabio | Zendy; Lechien Jerome R. | Zendy; Saussez Sven | Zendy; Vatrella Alessandro | Zendy; Salzano Francesco Antonio | Zendy; BoscoloRizzo Paolo | Zendy; Hopkins Claire | Zendy; De Riu Giacomo | Zendy

Open Access

Prevalence of Persistent Olfactory Disorders in Patients With COVID‐19: A Psychophysical Case‐Control Study With 1‐Year Follow‐up

Author(s) -

Vaira Luigi Angelo,

Salzano Giovanni,

Le Bon Serge Daniel,

Maglio Angelantonio,

Petrocelli Marzia,

Steffens Younes,

Ligas Enrica,

Maglitto Fabio,

Lechien Jerome R.,

Saussez Sven,

Vatrella Alessandro,

Salzano Francesco Antonio,

BoscoloRizzo Paolo,

Hopkins Claire,

De Riu Giacomo

Publication year - 2022

Publication title -

otolaryngology–head and neck surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.232

H-Index - 121

eISSN - 1097-6817

pISSN - 0194-5998

DOI - 10.1177/01945998211061511

Subject(s) - hyposmia , anosmia , interquartile range , covid-19 , medicine , population , case control study , olfaction , disease , biology , environmental health , ecology , infectious disease (medical specialty)

The purpose of this multicenter case‐control study was to evaluate a group of patients at least 1 year after coronavirus disease 2019 (COVID‐19) with Sniffin’ Sticks tests and to compare the results with a control population to quantify the potential bias introduced by the underlying prevalence of olfactory dysfunction (OD) in the general population. The study included 170 cases and 170 controls. In the COVID‐19 group, 26.5% of cases had OD (anosmia in 4.7%, hyposmia in 21.8%) versus 3.5% in the control group (6 cases of hyposmia). The TDI score (threshold, discrimination, and identification) in the COVID‐19 group was significantly lower than in the control group (32.5 [interquartile range, 29‐36.5] vs 36.75 [34‐39.5], P <. 001). The prevalence of OD was significantly higher in the COVID‐19 group, confirming that this result is not due to the underlying prevalence of OD in the general population.

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