Open AccessAssociation between Snoring and High‐Risk Carotid Plaque Features
Author(s) -
Kirkham Erin M.,
Hatsukami Thomas S.,
Heckbert Susan R.,
Sun Jie,
Canton Gador,
Yuan Chun,
Weaver Edward M.
Publication year - 2017
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599817715634
Subject(s) - medicine , sleep apnea , odds ratio , body mass index , asymptomatic , stroke (engine) , logistic regression , magnetic resonance imaging , obstructive sleep apnea , cardiology , radiology , mechanical engineering , engineering
Objectives Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self‐reported snoring and high‐risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke. Study Design Cross‐sectional. Setting Tertiary care university hospital and affiliated county hospital. Methods We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high‐resolution MRI. The survey captured data on self‐reported snoring (exposure) and covariates (age, sex, body mass index, and sleep apnea via the STOP‐Bang questionnaire). A subset of patients underwent home sleep apnea testing. High‐risk carotid plaque features were identified on the high‐resolution MRI and included thin/ruptured fibrous cap and intraplaque hemorrhage (outcomes). We quantified the association between snoring and high‐risk carotid plaque features with the chi‐square test (unadjusted analysis) and multivariate logistic regression adjusting for the covariates. Results Of 133 subjects surveyed, 61 (46%) responded; 32 (52%) reported snoring. Significantly higher proportions of snorers than nonsnorers had a thin/ruptured fibrous cap (56% vs 25%, P =. 01) and intraplaque hemorrhage (63% vs 29%, P <. 01). In multivariate analysis, snoring was associated with thin/ruptured fibrous cap (odds ratio, 4.4; 95% CI, 1.1‐16.6; P =. 04) and intraplaque hemorrhage (odds ratio, 8.2; 95% CI, 2.1‐31.6; P <. 01) after adjusting for age, sex, body mass index, and sleep apnea. Conclusion This pilot study suggests a significant independent association between snoring and high‐risk carotid plaque features on MRI. Further study is warranted to confirm these results in a larger cohort of subjects.