Open AccessPanel 8: Report on Recent Advances in Molecular and Cellular Biochemistry
Author(s) -
Preciado Diego,
Granath Anna,
Lin Jizhen,
Val Stéphanie,
Kurabi Arwa,
Johnston Nikki,
Vijayasekaran Shyan,
Valdez Tulio,
Depireux Didier,
Hermansson Ann
Publication year - 2017
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599816658290
Subject(s) - otitis , disease , biology , bioinformatics , computational biology , medicine , pathology , genetics
Objectives To update the medical literature on recent cellular and molecular advances in otitis media disease models with a principal focus on developments in the past 5 years. We also aim to explain recent translational advances in cellular and molecular biology that have influenced our understanding and management of otitis media. Data Sources PubMed‐indexed peer‐reviewed articles. Review Methods A comprehensive review of the literature was conducted with the term otitis media and the following search terms: molecular biology, cell biology, innate immunity, oxidative stress, mucins, molecular diagnostics . Included articles were published in the English language from January 1, 2010, to July 31, 2015. Implications for Practice The molecular understanding of otitis media disease progression has rapidly advanced over the last 5 years. The roles of inflammation, mucins, and cell signaling mechanisms have been elucidated and defined. Advances in the field provide a plethora of opportunities for innovative molecular targeting in the development of novel therapeutic strategies for otitis media.