Open AccessHuman Papilloma Virus in Laryngeal Squamous Cell Carcinoma
Author(s) -
Clayburgh Daniel,
Sauer David,
Schindler Joshua S.
Publication year - 2012
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599812451438a75
Subject(s) - medicine , incidence (geometry) , human papilloma virus , gastroenterology , laryngeal neoplasm , carcinoma , basal cell , disease , oncology , papilloma , pathology , cancer , cervical cancer , physics , optics
Objective 1) To determine the incidence of human papilloma virus (HPV) expression in laryngeal squamous cell carcinoma (SCC). 2) To determine the subtypes of HPV associated with laryngeal SCC. Method Between 2006 and 2011, most new diagnoses of laryngeal SCC at our institution were sent for HPV PCR. A retrospective review was conducted on these patients. The results of this test, patient history, and tumor characteristics were collected. Descriptive statistics and Student’s t test were performed. Results Thirty patients with laryngeal SCC and an HPV PCR assay were identified. Three patients (10%) were positive for HPV. Subtypes 16, 31, and 59 were identified in these 3 patients. The HPV+ patients exhibited a trend towards less tobacco use (23 pack‐years versus 46 pack‐years in HPV– patients), although this was not statistically significant ( P =. 18). There was no significant difference in age between HPV+ and HPV– patients (63.3 years vs 65.8 years, P =. 88). Conclusion Although not as common as in oropharyngeal SCC, a subset of laryngeal SCC is associated with HPV. Several subtypes of HPV may be found in this disease. Future prospective studies will be useful to more accurately determine the incidence of HPV in laryngeal SCC and its effects on disease outcomes.