Open AccessHuman Papillomavirus in Sinonasal Diseases
Author(s) -
Suzuki Mikio,
Hasegawa Masahiro,
Deng Zeyi,
Maeda Hiroyuki,
Kiyuna Asanori,
Uehara Takayuki
Publication year - 2012
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599812451426a395
Subject(s) - viral load , human papillomavirus , pathogenesis , medicine , polymerase chain reaction , lesion , hpv infection , immunology , virus , pathology , biology , cancer , cervical cancer , gene , biochemistry
Objective This study investigated prospectively the role of human papillomavirus (HPV) in various sinonasal diseases. Method HPV presence and viral load and physical status of HPV‐16 were examined by polymerase chain reaction‐based methods using fresh frozen samples obtained from 13 patients with IP (IP group), 11 with squamous cell carcinoma in the maxillary sinus (SCC group), and 39 with chronic inflammatory lesions (inflammatory group). Results The presence of the HPV genome was detected in 46.1%, 27.3%, and 7.6% of patients in the IP, SCC and inflammatory groups, respectively. The IP group showed significantly higher HPV‐positive rates than the inflammatory group. All types of HPV detected were high‐risk HPV, especially HPV‐16. The relative HPV‐16 copy numbers varied from 2.5 to 1524.1 per 50 ng genomic DNA. Viral load was higher in the IP and SCC groups than in the inflammatory group. In the IP group, no significant relationship was found between HPV‐16 viral load and clinical characteristics, or between physical status and clinical characteristics. Conclusion HPV infection is involved in the pathogenesis of IP, and high viral load and integration of HPV have an important role in malignant lesion in association with IP.