Open AccessExperimental Laryngeal Granuloma in Rats with GERD
Author(s) -
Shimazu Rintaro,
Kuratomi Yuichiro,
Inokuchi Akira
Publication year - 2012
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599812451426a209
Subject(s) - larynx , granuloma , medicine , pathological , laryngeal diseases , pathology , pharynx , esophagus , cord , reflux esophagitis , anatomy , reflux , surgery , disease
Objective Acid reflux and mucosal injury of the larynx may be involved in the development of laryngeal granuloma. This study developed an experimental laryngeal granuloma by mechanical injury to the vocal cord mucosa in rats with chronic acid refluesophagitis to clarify the pathological mechanism of laryngeal granuloma. Method An experimental rat model of chronic acid reflux esophagitis was surgically created. A plastic bar was inserted into the trachea of the model rat to mechanically injure the vocal cord mucosa. The pharynx, larynx, and esophagus of these rats were observed histologically every 2 weeks after the operation. Results A granuloma was observed in the vocal cord mucosa of the rat after 2 weeks of the surgery, and this presented the same pathological structure as human laryngeal granuloma. In contrast, only mucosal abrasions and blister formations of the vocal cord mucosa were observed in the control rats without surgery. Conclusion The current results showed both mechanical injury and acid refluwas involved in the development of a laryngeal granuloma.