Open AccessMammary Analogue Secretory Carcinoma of the Parotid Gland
Author(s) -
Huang Lilleen M.,
Petersson Frederik,
Loke David
Publication year - 2012
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599812451426a129
Subject(s) - acinic cell carcinoma , etv6 , salivary gland , parotid gland , fusion gene , cystadenocarcinoma , mammary gland , pathology , chromosomal translocation , carcinoma , gene , biology , medicine , cancer research , adenocarcinoma , cancer , genetics , breast cancer , mucoepidermoid carcinoma
Objective Mammary analogue secretory carcinoma is a new entity in salivary gland tumors that has only been recently described. It has overlapping histopathological features with acinic cell carcinoma and low grade variants of cystadenocarcinoma. It has a distinct chromosomal translocation, t(12;15)‐(p13;q25), resulting in a fusion gene ETV6 NTRK3. The clinical course of this disease entity is uncertain at present. We present a case of MASC of the parotid gland occurring in a 34‐year‐old man and discuss the difficulties in diagnosis and subsequent treatment of this tumour.