Open AccessHigh Prevalence of Hearing Impairment in HIV‐Infected Peruvian Children
Author(s) -
Chao Christina K.,
Czechowicz Josephine A.,
Messner Anna H.,
Alarcón Jorge,
Kolevic Roca Lenka,
Larragán Rodriguez Marsi M.,
Gutiérrez Villafuerte César,
Montano Silvia M.,
Zunt Joseph R.
Publication year - 2012
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599811429271
Subject(s) - human immunodeficiency virus (hiv) , prevalence , audiology , medicine , virology , pediatrics , epidemiology
Objectives To measure the prevalence and to identify risk factors of hearing impairment in human immunodeficiency virus‐infected children living in Peru. Study design Cross‐sectional observational study. Setting Two public hospitals and 1 nonprofit center in Lima, Peru, between August 2009 and April 2010. Subjects A total of 139 HIV‐infected children, ages 4 to 19 years. Methods Hearing impairment and otologic health were assessed with pure tone audiometry, tympanometry, and otoscopy. The primary outcome was hearing loss, defined as average threshold >25dB for 0.5, 1, 2, and 4 kHz, in one or both ears. Historical and socioeconomic information was obtained through parental survey and medical chart review. Statistical analysis included univariate analysis and multivariate logistic regression. Results Fifty‐four (38.8%) of 139 children had hearing impairment. On multivariate analysis, risk factors included: tympanic membrane perforation (odds ratio [OR] 7.08; 95% confidence interval [CI], 1.65‐30.5; P =. 01), abnormal tympanometry (OR 2.71; 95% CI, 1.09‐6.75; P =. 03), cerebral infection (OR 11.6; 95% CI, 1.06‐126; P =. 05), seizures (OR 5.20; 95% CI, 1.21‐22.4; P =. 03), and CD4 cell count <500 cells/mm 3 (OR 3.53; 95% CI, 1.18‐10.5; P =. 02). Conclusions The prevalence of hearing impairment in HIV‐infected children in Lima, Peru was 38.8%. Middle ear disease, prior cerebral infection, and low CD4 cell count were significantly associated with hearing impairment. The high prevalence of hearing impairment emphasizes the need for periodic hearing assessment in the routine clinical care of HIV‐infected children.