Open AccessSystemic Erdosteine against Cisplatin‐Induced Ototoxicity
Author(s) -
Waissbluth Sofia,
Dupuis Isabelle,
Daniel Sam J.
Publication year - 2011
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599811416318a192
Subject(s) - ototoxicity , cisplatin , systemic administration , pharmacology , guinea pig , cochlea , toxicity , auditory brainstem response , medicine , limiting , hair cell , intraperitoneal injection , anesthesia , chemotherapy , hearing loss , anatomy , biology , audiology , in vivo , mechanical engineering , microbiology and biotechnology , engineering
Objective Cisplatin is a commonly used chemotherapeutic agent. One of its major dose limiting side effects is ototoxicity. No treatment has yet been approved for this condition. The objective of this study was to determine the potential protective effect of a systemic administration of erdosteine against cisplatin‐induced ototoxicity. Method Guinea pigs were assigned to 4 groups, each receiving a different concentration of intraperitoneal erdosteine: 0, 100, 200, and 500 mg/kg/d for 4 days. All of the animals received 12 mg/kg/d of intraperitoneal cisplatin. Auditory brainstem response (ABR), scanning electron microscopy, and outer hair cell counts were performed. Results Significant otoprotection was observed in groups receiving 200 and 500 mg/kg/d of erdosteine as demonstrated by high frequency (25 kHz) ABR threshold shifts. These findings are supported by outer hair cell counts by scanning electron microscopy. Guinea pigs receiving 100 mg/kg/d did not present otoprotection. Conclusion A systemic administration of erdosteine appears to provide a significant otoprotective effect at the basal area of the cochlea for cisplatin‐induced ototoxicity in a guinea pig model.