Open AccessHPV‐Positive Outcomes in an Access to Care Laryngeal Squamous Cell Cancer Cohort
Author(s) -
Stephen Josena K.,
Mei Lu,
Harvard Shaleta,
Gardner Glendon M.,
Chen KangMei,
Schweitzer Vanessa,
Worsham Maria J.
Publication year - 2011
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599811416318a127
Subject(s) - medicine , oncology , context (archaeology) , cohort , human papillomavirus , exact test , cancer , squamous cell cancer , hpv infection , cervical cancer , biology , paleontology
Objective Oncogenic human papillomavirus (HPV) has been established as a causative agent for 25% of head and neck squamous cell cancer (HNSCC), including laryngeal squamous cell cancer (LSCC). HPV‐positive oropharyngeal patients have improved prognosis. We determined outcomes in LSCC in the context of HPV infection. Method Seventy‐nine primary LSCC were examined for 21 risk factors. HPV status was determined using real‐time quantitative PCR. Chi‐square/Fisher exact test were used to test association of HPV‐positive with the other risk factors. Kaplan‐Meier and log rank test were used to study the risk of HPV‐positive status for overall survival. Results HPV‐16 was detected in 21 out of 77 (27%) primary LSCC, 16% (5/32) African American (AA) and 33% (15/45) Caucasian American (CA). Significance between race and HPV status was marginal ( P =. 058). HPV‐positive status was significantly associated with male gender ( P =. 017) and insurance type ( P =. 001). HPV‐positive LSCC had longer median survival (6.64 years) when compared with HPV‐negative (6.25 years), but was not significant. Conclusion We found high prevalence of HPV in males vs females and lower prevalence of HPV infection in AA vs CA. Larger multi‐ethnic LSCC cohorts are needed to more clearly delineate HPV‐related survival outcomes across ethnicities.