Open AccessStaphylococcus Aureus Enterotoxins in Chronic Rhinosinusitis
Author(s) -
Cheng Lei,
Zhu Luping
Publication year - 2011
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599811415823a429
Subject(s) - superantigen , nasal polyps , staphylococcus aureus , chronic rhinosinusitis , pathogenesis , enterotoxin , medicine , immunology , immunoglobulin e , sinusitis , staphylococcal infections , biology , antibody , gene , t cell , immune system , bacteria , genetics , biochemistry , escherichia coli
Objective Analyze the role of Staphylococcus aureus enterotoxins (SEs) in the pathogenesis of chronic rhinosinusitis (CRS) with and without nasal polyps (CRSwNP and CRSsNP). Method Forty patients with CRSwNP, 30 patients with CRSsNP, and 30 healthy controls were enrolled in the study. Serum specific IgE against SEA, SEB, and SEC was measured using ImmunoCAP 100E system, and statistical analysis was performed by SPSS 13.0 software. Results The serum level of specific IgE to SEB in patients with CRSwNP or CRSsNP was significantly higher than that in controls, respectively ( P =. 05). Conclusion Staphylococcal superantigen SEB may play a role in the development of CRS with or without nasal polyps.