Open AccessEffects of Hepatocyte Growth Factor Injection and Reinjection
Author(s) -
Garcia Roberta Ismael Dias,
Tsuhji Domingos Hiroshi,
Imamura Luiz F.,
Bissoli Rui,
Mauad Thais
Publication year - 2011
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599811415823a185
Subject(s) - lamina propria , vocal folds , hepatocyte growth factor , anatomy , medicine , pathology , epithelium , chemistry , larynx , receptor
Objective The study sought to assess the effects of HGF injection and reinjection coinciding with its peak of activity on collagen density, vessel density, inflammatory reaction in the lamina propria, and mean epithelial thickness in the injured rabbit vocal fold. Method Fourteen rabbits were subdivided in group 1 that received HGF injections into the right vocal fold and 2 that received bilateral HGF injections and reinjection into the right vocal fold 10 days after. Left vocal folds were controls. Histological assessment was performed at 30 and 40 days respectively. Results In both groups, collagen density was lower in the right vocal folds than in the left folds ( P =. 018). Vessel density was higher in the right vocal folds in group 2 ( P =. 018). Differences about mean epithelial thickness and inflammatory reaction in the lamina propria are not statistical significance. Conclusion In the scarred rabbit vocal fold, HGF injection is associated with decreased collagen density in the lamina propria, whereas reinjection after 10 days produces decreased collagen density and higher vessel density.