Open AccessNasal Passages of Göttingen Minipigs from the Neonatal Period to Young Adult
Author(s) -
C. Frieke Kuper,
Heinrich Ernst,
Lidy C. M. van Oostrum,
Susanne Rittinghausen,
André Penninks,
Niels-Christian Ganderup,
André Wolterbeek
Publication year - 2012
Publication title -
toxicologic pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.613
H-Index - 108
eISSN - 1533-1601
pISSN - 0192-6233
DOI - 10.1177/0192623311436175
Subject(s) - vomeronasal organ , pathology , histology , physiology , medicine , lesion , respiratory system , nasal cavity , inhalation , olfactory bulb , anatomy , biology , olfactory system , central nervous system , psychiatry
Histopathological examination of the nasal passages requires a standardized approach for recording lesion distribution patterns. Nasal diagrams provide guidance to map the lesions. Information on lesions exists for rodents, dogs, and monkeys, which all have been used in inhalation studies. Recently, minipigs have garnered interest as an inhalation model because minipigs resemble humans in many features of anatomy, physiology, and biochemistry and may be a good alternative to monkeys and dogs. The present work explored the microanatomy and histology of the nasal passages of Göttingen minipigs from postnatal day 1 until 6 months of age. Six nasal levels were selected, which allow examination of the squamous, transitional (nonciliated) and ciliated respiratory, and olfactory epithelia; the nasopharynx; and relevant structures such as the vomeronasal organ, olfactory bulb, and nasal/nasopharynx-associated lymphoid tissue.