Unintended Effects of Cranial Irradiation on Cognitive Function | Zendy

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Unintended Effects of Cranial Irradiation on Cognitive Function

Author(s) -

Jacob Raber

Publication year - 2009

Publication title -

toxicologic pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.613

H-Index - 108

eISSN - 1533-1601

pISSN - 0192-6233

DOI - 10.1177/0192623309352003

Subject(s) - neurogenesis , adverse effect , oxidative stress , medicine , unintended consequences , cognition , neuroscience , physiology , psychology , political science , law

This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.

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