Psychiatric Morbidity in Adults with Hypopituitarism | Zendy

S. Lynch | Zendy; Stephen Merson | Zendy; Salem Beshyah | Zendy; E. ROY SKINNER | Zendy; P. S. Sharp | Zendy; R. G. Priest | Zendy; D. G. Johnston | Zendy

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Psychiatric Morbidity in Adults with Hypopituitarism

Author(s) -

S. Lynch,

Stephen Merson,

Salem Beshyah,

E. ROY SKINNER,

P. S. Sharp,

R. G. Priest,

D. G. Johnston

Publication year - 1994

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107689408700805

Subject(s) - hypopituitarism , medicine , depression (economics) , diabetes mellitus , psychiatry , odds ratio , growth hormone deficiency , pediatrics , endocrinology , growth hormone , hormone , economics , macroeconomics

Forty-one adults with established hypopituitarism and deficiency of growth hormone (GHD) were compared to an age and sex-matched group with another chronic metabolic disorder (diabetes mellitus) using standardized psychiatric rating and diagnostic measures. Nineteen (46%) of the GHD group were identified as definite psychiatric cases compared with 10 (24%) of the diabetics (odds ratio 1:9:1). The most frequent DSM III-R axis I psychiatric diagnoses were major depression (32% GHD patients and 10% of diabetic patients) and dysthymia. The risk of being a psychiatric case showed an association with duration of illness in the diabetic group, but not in the GHD group. Biochemical indices were not related to the risk of being a case in either group. Hypopituitarism is associated with a higher prevalence of psychiatric disturbance than can be attributed solely to the presence of a chronic disorder.

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