Histological and Environmental Changes in Longstanding Ileal Conduits | Zendy

D J B Thomas | Zendy; N. M. GOBLE | Zendy; David Gillatt | Zendy; J. C. HAMMONDS | Zendy; Patrick J. Smith | Zendy

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Histological and Environmental Changes in Longstanding Ileal Conduits

Author(s) -

D J B Thomas,

N. M. GOBLE,

David Gillatt,

J. C. HAMMONDS,

Patrick J. Smith

Publication year - 1990

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107689008300908

Subject(s) - pathology , anastomosis , mucin , metaplasia , histology , hyperplasia , crypt , medicine , intestinal metaplasia , biopsy , villous atrophy , biology , surgery , dysplasia , coeliac disease , disease

Seventeen patients with urinary diversions present for between 10 and 17 years were examined endoscopically. The region of the anastomosis was successfully biopsied in 13 cases. Biopsy specimens were examined both histologically and cytologically. Urine was aspirated from the conduits under sterile conditions and sent for qualification of bacterial flora. Histology revealed a variable degree of villous atrophy, mucosal metaplasia, crypt hyperplasia and in one case, antral type gland metaplasia. The finding of hyperplasia was corroborated by flow cytometry which demonstrated a high percentage of cells in G2 and metaphase. The majority of cases showed a colonic type of bacterial colonization and mucin histochemistry demonstrated a colonic type of mucin.

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