Hyponatraemia and Moduretic-Grand Mal Seizures: A Review | Zendy

C Johnston | Zendy; Lynsey Webb | Zendy; James Daley | Zendy; G.S. Spathis | Zendy

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Hyponatraemia and Moduretic-Grand Mal Seizures: A Review

Author(s) -

C Johnston,

Lynsey Webb,

James Daley,

G.S. Spathis

Publication year - 1989

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688908200811

Subject(s) - hydrochlorothiazide , medicine , amiloride , intensive care medicine , etiology , grand mal , pediatrics , epilepsy , psychiatry , sodium , blood pressure , chemistry , organic chemistry

Three cases are presented which emphasize the importance of hyponatraemia as a cause of grand mal seizures. The combination of hydrochlorothiazide and amiloride appears to increase the risk of hyponatraemia. We discuss the aetiology and treatment of hyponatraemia and review the necessity for such combination therapy. We recommend caution in prescribing diuretics and preparations such as Moduretic should be used only in those few patients shown to need potassium supplementation.

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