Open AccessModulating the Oxygen Tension in Tumours by Hypothermia and Hyperbaric Oxygen
Author(s) -
A.H.W. Nias,
Paul Perry,
Α. Φωτίου
Publication year - 1988
Publication title -
journal of the royal society of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.38
H-Index - 81
eISSN - 1758-1095
pISSN - 0141-0768
DOI - 10.1177/014107688808101106
Subject(s) - hypothermia , oxygen , oxygen tension , hyperbaric oxygen , medicine , oxygen metabolism , arterial oxygen tension , blood supply , anesthesia , metabolism , chemistry , surgery , organic chemistry
Hypothermia is associated with reduced metabolism of tissues and especially reduced oxygen consumption by tumours. If the blood supply to a hypothermic tumour can be maintained then the hypoxic fraction of cells should be reduced and the radiation response increased. This hypothesis has been tested with radiation under hyperbaric oxygen and increased tumour response has been demonstrated.
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