Open AccessPhenylephrine-Induced Reversible Cataract in the Mouse
Author(s) -
Charles Claoué
Publication year - 1987
Publication title -
journal of the royal society of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.38
H-Index - 81
eISSN - 1758-1095
pISSN - 0141-0768
DOI - 10.1177/014107688708001112
Subject(s) - phenylephrine , lens (geology) , ophthalmology , medicine , optometry , biology , blood pressure , paleontology
Topical 10% phenylephrine will produce lens opacities in several strains of mouse. These lens opacities resolve spontaneously within 24 hours, leaving an apparently normal eye. Phenylephrine-induced lens opacification in the mouse can be prevented by covering the eye with ointment, suggesting that the underlying mechanism is transcorneal dehydration.
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