Effects of Cytotoxic Chemotherapy on Dental Development | Zendy

R I Macleod | Zendy; Richard Welbury | Zendy; J.V. Soames | Zendy

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Effects of Cytotoxic Chemotherapy on Dental Development

Author(s) -

R I Macleod,

Richard Welbury,

J.V. Soames

Publication year - 1987

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688708000405

Subject(s) - cytotoxic t cell , odontoblast , vincristine , calcification , chemotherapy , cytotoxicity , pathology , medicine , cancer research , chemistry , dentin , biochemistry , in vitro , cyclophosphamide

A histological study of 21 teeth from 9 patients who had received cytotoxic chemotherapy for malignant disease showed increased prominence of incremental lines in the dentine. The number and distribution of these lines corresponded to periods of intravenous therapy and vincristine appeared to be the most likely cause. This effect was probably due to temporary disturbance of microtubular function in the odontoblasts resulting in decreased secretion of collagenous dentine matrix. Calcification appeared to be unaffected.

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