Histamine and its Release from Nasal Polyps: Preliminary Communication | Zendy

Adrian DrakeLee | Zendy

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Histamine and its Release from Nasal Polyps: Preliminary Communication

Author(s) -

Adrian DrakeLee

Publication year - 1984

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688407700210

Subject(s) - histamine , nasal polyps , immunoglobulin e , allergen , degranulation , polypectomy , house dust mite , medicine , immunology , allergy , mite , mast cell , biology , antibody , receptor , botany , colorectal cancer , colonoscopy , cancer

Two hundred consecutive patients admitted for polypectomy had no evidence of an increased incidence of allergic disorders. Mast cell degranulation was found on transmission electron microscopy and this resulted in considerable quantities of histamine in polyp extracellular fluid (124-7300 ng/ml). RAST levels of allergen-specific IgE to house-dust mite and mixed-grass pollens were raised in 4 out of 28 cases in polyp fluid, and in only one matched serum. In vitro challenge of polyp tissue with allergen extract and anti-IgE suggested an IgE-mediated response in only 4 of 36 patients.

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