Chemotherapy of Endodermal Sinus Tumour (Yolk Sac Tumour) of the Ovary: Preliminary Communication | Zendy

E. Wiltshaw | Zendy; R. StuartHarris | Zendy; G H Barker | Zendy; N. F. C. Gowing | Zendy; Sivashanmugam Raju | Zendy

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Chemotherapy of Endodermal Sinus Tumour (Yolk Sac Tumour) of the Ovary: Preliminary Communication

Author(s) -

E. Wiltshaw,

R. StuartHarris,

G H Barker,

N. F. C. Gowing,

Sivashanmugam Raju

Publication year - 1982

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688207501113

Subject(s) - endodermal sinus tumor , bleomycin , yolk sac , vinblastine , ovary , cisplatin , chemotherapy , immature teratoma , medicine , etoposide , combination chemotherapy , dysgerminoma , regimen , germ cell , teratoma , surgery , pathology , germ cell tumors , biology , embryo , biochemistry , gene , microbiology and biotechnology

Eight patients presenting with endodermal sinus tumour of the ovary have been treated with combination chemotherapy using cisplatin, bleomycin and vinblastine (PVB). Complete remission occurred in 7 out of 8 cases, all of whom are alive and well 3 to 33 months later. These preliminary results are compared with our own past experience and recent reports in the literature. It is concluded that the PVB regimen is probably as effective in female germ cell tumours as it is in testicular teratoma.

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