Saline Flush: A Simple Method of Reducing Diazepam-Induced Thrombophlebitis | Zendy

Micheal Dutt | Zendy; R. P. H. Thompson | Zendy

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Saline Flush: A Simple Method of Reducing Diazepam-Induced Thrombophlebitis

Author(s) -

Micheal Dutt,

R. P. H. Thompson

Publication year - 1982

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688207500404

Subject(s) - thrombophlebitis , saline , diazepam , simple (philosophy) , medicine , anesthesia , surgery , computer science , thrombosis , philosophy , epistemology

Five hundred outpatients undergoing endoscopy were admitted into a controlled trial comparing the incidence of thrombophlebitis following intravenous diazepam administered in the way, with the effects of either a saline flush following the diazepam or diluting the drug with the patient's own blood before injection ('barbotage'). The results were assessed using a questionnaire completed by patients two weeks after endoscopy; 80% replied. A saline flush reduced the incidence of side effects, particularly pain (P less than 0.05). 'Barbotage' gave the highest incidence of side effects. Saline flush is therefore recommended as a means of reducing the thrombophlebitis which may follow intravenous diazepam.

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