Effect of Inhaled Alpha-Blocker on Airflow Obstruction in Asthma1 | Zendy

John Britton | Zendy; Jon G. Ayres | Zendy; G.M. Cochrane | Zendy

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Effect of Inhaled Alpha-Blocker on Airflow Obstruction in Asthma¹

Author(s) -

John Britton,

Jon G. Ayres,

G.M. Cochrane

Publication year - 1981

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688107400904

Subject(s) - asthma , inhalation , placebo , medicine , alpha (finance) , anesthesia , airflow , bronchodilator agents , β2 adrenergic receptor , cardiology , bronchodilator , receptor , surgery , pathology , patient satisfaction , physics , construct validity , alternative medicine , agonist , thermodynamics

A controlled study of the effect on airflow obstruction of 30 mg of the alpha-blocker thymoxamine given by inhalation is reported in 10 patients with chronic stable asthma. No significant change in peak expiratory flow rate was seen with either thymoxamine or placebo in any patient. Alpha-adrenergic receptors are therefore unlikely to contribute significantly to resting bronchomotor tone in chronic stable asthma.

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