Comparison of the Effects of Atropine and Glycopyrrolate on various End-Organs1 | Zendy

R. K. Mirakhur | Zendy; JOHN W. DUNDEE | Zendy

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Comparison of the Effects of Atropine and Glycopyrrolate on various End-Organs¹

Author(s) -

R. K. Mirakhur,

JOHN W. DUNDEE

Publication year - 1980

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688007301008

Subject(s) - glycopyrrolate , atropine , parasympatholytic , cholinergic , medicine , scopolamine , endocrinology , pharmacology , anesthesia , chemistry , muscarinic acetylcholine receptor , receptor

Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.

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