Radioimmunolocalization of Tumours by External Scintigraphy after Administration of131I Antibody to Human Chorionic Gonadotrophin: Preliminary Communication | Zendy

Richard H. J. Beǵent | Zendy; F Searle | Zendy; Glyn Stanway | Zendy; R. F. Jewkes | Zendy; B. E. Jones | Zendy; Peter Ver | Zendy; K D Bagshawe | Zendy

Open Access

Radioimmunolocalization of Tumours by External Scintigraphy after Administration of¹³¹I Antibody to Human Chorionic Gonadotrophin: Preliminary Communication

Author(s) -

Richard H. J. Beǵent,

F Searle,

Glyn Stanway,

R. F. Jewkes,

B. E. Jones,

Peter Ver,

K D Bagshawe

Publication year - 1980

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688007300905

Subject(s) - scintigraphy , medicine , nuclear medicine , antibody , human chorionic gonadotropin , gynecology , pathology , endocrinology , hormone , immunology

131 Iodine ( 131 I) labelled antibody directed against human chorionic gonadatrophin (hCG) was given on 21 occasions to 18 patients with hCG-producing neoplasms. Tumours were localized by external scintigraphy in 13 of 21 investigations. Positive results were obtained reliably when serum hCG exceeded 500 miu/ml and in some cases sensitivity was comparable to that of computerized tomography. A positive result probably implies viability in the tumour and this was of practical value in discriminating between necrotic deposits and living tumour before surgery.

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