Neuropharmacological agents modifying endotoxin-induced changes in mice | Zendy

David J. Wright | Zendy; Malcolm Weller | Zendy

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Neuropharmacological agents modifying endotoxin-induced changes in mice

Author(s) -

David J. Wright,

Malcolm Weller

Publication year - 1980

Publication title -

journal of the royal society of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 81

eISSN - 1758-1095

pISSN - 0141-0768

DOI - 10.1177/014107688007300608

Subject(s) - chlorpromazine , reserpine , propranolol , pharmacology , fusaric acid , blockade , medicine , adrenergic receptor , phenoxybenzamine , chemistry , receptor , endocrinology , biology , fusarium , horticulture

A variety of neuropharmacological agents were tested to elucidate how chlorpromazine influenced an endotoxin-induced reaction. The results obtained, particularly with beta-adrenergic blocking agents, reserpine and fusaric acid, suggested that the primary locus of chlorpromazine's action was mediated by peripheral beta-adrenergic receptor blockade. Such a locus is compatible with the low doses of propranolol which suppress the reaction, and with successful treatment of shock with dopamine.

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