Events

and the Sex-hormone; Their Interrelations" based on work done in his own laboratory, was from the broad viewpoint of general biology, rather than from the narrower aspect of endocrinology proper. The relation of insulin to adrenalin was illustrated by microscopic sections of the adrenal medulla and cortex, derived from both normal rats and those treated with insulin. The relative amount of the adrenalin deposit in each case was measured by counting the chromaflin cells. The effect of insulin was to decrease the adrenal deposits. This was interpreted as due, not to an actual decrease in the rate of secretion, but to a pouring out of the adrenalin into the blood stream. A positive correlation could be shown between the internal secretion of the corpus luteum tissue of the ovary and the amount of the adrenalin in the so-called ganglion cervicis uteri. During pregnancy , the amount of adrenalin in this ganglion steadily increased, reaching a maximum just before parturition. Teleologically, one can perhaps assume that it is the function of this adrenalin deposit to make possible the vigorous contraction of the uterus necessary for parturition. Castration greatly reduced the amounts of adrenalin formed, but the subsequent injection of ovary extract increased the number of chromaffin cells. Similar effects were produced by turnip or potato juice. In addition to these relationships, there is an interrelation between the sex-hormone and the secretion of the islands of Langer-hans, since an increase in sex-hormone secretion also increased the secretion of insulin. Thus the three principles are so related that an increase or decrease in any one secretion will destroy the existing equilibrium and set up a new one on a higher or lower plane of activity. Probably other endocrine glands of the body are involved and concerning these further studies are now in progress. The futility of dividing an