Open AccessExpression of Notch1 and Jagged2 in the Enteric Nervous System
Author(s) -
Guy R. Sander,
Simon J. Brookes,
Barry C. Powell
Publication year - 2003
Publication title -
journal of histochemistry and cytochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 124
eISSN - 1551-5044
pISSN - 0022-1554
DOI - 10.1177/002215540305100712
Subject(s) - enteric nervous system , myenteric plexus , notch signaling pathway , biology , calretinin , nervous system , immunohistochemistry , microbiology and biotechnology , signal transduction , neuroscience , immunology
The Notch signaling pathway is a vitally important pathway in regulating brain development. To explore the involvement of the Notch pathway in neuronal cells of adult rat gut, we investigated the expression of Notch1 and Jagged2 by in situ hybridization (ISH) and immunohistochemistry (IHC). In the enteric nervous system, Notch1 and Jagged2 were expressed in ganglia of the submucosal and myenteric plexus. Notch1 was preferentially expressed in cholinergic neurons lacking calretinin or nitric oxide synthase (NOS), whereas Jagged2 was present in most neuron subtypes. We propose that Notch1 and Jagged2 have a continuing role in the maintenance and function of neuronal cells in the adult enteric nervous system.
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