Open AccessPreliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression
Author(s) -
Boadie W. Dunlop,
Mary E. Kelley,
Callie L. McGrath,
W. Edward Craighead,
Helen S. Mayberg
Publication year - 2015
Publication title -
the journal of neuropsychiatry and clinical neurosciences/the journal of neuropsychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 108
eISSN - 1545-7222
pISSN - 0895-0172
DOI - 10.1176/appi.neuropsych.14030048
Subject(s) - biomarker , escitalopram , insula , depression (economics) , citalopram , medicine , oncology , psychology , psychiatry , neuroscience , anxiety , biochemistry , chemistry , macroeconomics , economics , antidepressant
A putative right anterior insula metabolism biomarker predictive of treatment outcomes was retrospectively applied to 30 depressed psychotherapy--or escitalopram-treated nonremitters who entered combination treatment. Patients whose added treatment matched the biomarker-indicated treatment remitted more often than biomarker-mismatched patients.