Open AccessFrontal White Matter Biochemical Abnormalities in Late-Life Major Depression Detected With Proton Magnetic Resonance Spectroscopy
Author(s) -
Anand Kumar,
Albert Thomas,
Helen Lavretsky,
Kenneth Yue,
Amir Huda,
John Curran,
Talaignair N. Venkatraman,
Laverne Estanol,
Jim Mintz,
Michael S. Mega,
Arthur W. Toga
Publication year - 2002
Publication title -
the american journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.477
H-Index - 353
eISSN - 1535-7228
pISSN - 0002-953X
DOI - 10.1176/appi.ajp.159.4.630
Subject(s) - creatine , white matter , choline , magnetic resonance imaging , metabolite , medicine , late life depression , psychology , voxel , depression (economics) , grey matter , nuclear magnetic resonance , endocrinology , nuclear medicine , radiology , physics , macroeconomics , hippocampal formation , economics
Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy.