Open AccessHuman Lymphocytes Bear Membrane Receptors for C3b and C3d
Author(s) -
Aline Eden,
Gary W. Miller,
Victor Nussenzweig
Publication year - 1973
Publication title -
the journal of clinical investigation/the journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.278
H-Index - 488
eISSN - 1558-8238
pISSN - 0021-9738
DOI - 10.1172/jci107525
Subject(s) - receptor , immune adherence , antibody , rosette formation , peripheral blood , biology , trypsin , complement receptor , cell surface receptor , rosette (schizont appearance) , immunology , complement system , human blood , microbiology and biotechnology , chemistry , biochemistry , enzyme , hemagglutination , physiology
Human peripheral blood lymphocytes have membrane receptors for EAC43b (sheep erythrocytes sensitized with antibody and complement) and also for EAC43d, obtained by treating EAC43b with C3b inactivator. Human granulocytes bind only EAC43b, C3 fragments obtained by limited trypsin digestion of purified human C3 display both C3b and C3d sites, since they inhibit rosette formation of lymphocytes with EAC43b and EAC43d. These findings raise the possibility that C3b and C3d receptor sites may be selectively distributed among normal subpopulations of B lymphocytes as well as among leukemic leukocytes.