Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy | Zendy

Suhwan Lee | Zendy; Im Kyeung Kang | Zendy; Ji Hyun Kim | Zendy; Bok Kyoung Jung | Zendy; Keerang Park | Zendy; Heesoon Chang | Zendy; Joo Yong Lee | Zendy; Heuiran Lee | Zendy

Open Access

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

Author(s) -

Suhwan Lee,

Im Kyeung Kang,

Ji Hyun Kim,

Bok Kyoung Jung,

Keerang Park,

Heesoon Chang,

Joo Yong Lee,

Heuiran Lee

Publication year - 2019

Publication title -

translational vision science and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.508

H-Index - 21

ISSN - 2164-2591

DOI - 10.1167/tvst.8.2.14

Subject(s) - medicine , vitrectomy , ophthalmology , retinal , epiretinal membrane , blood–retinal barrier , antibody , titer , vitreous hemorrhage , fluorescein angiography , retinal detachment , immunology , visual acuity , diabetic retinopathy , endocrinology , diabetes mellitus

This study provides substantial basis for retinal gene therapy using AAVs and how maintenance of BRB integrity in target diseases should be considered.

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