Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma | Zendy

Ian Pitha | Zendy; Ericka Oglesby | Zendy; Amanda Chow | Zendy; Elizabeth Kimball | Zendy; Mary Ellen Pease | Zendy; Julie Schaub | Zendy; Harry A. Quigley | Zendy

Open Access

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

Author(s) -

Ian Pitha,

Ericka Oglesby,

Amanda Chow,

Elizabeth Kimball,

Mary Ellen Pease,

Julie Schaub,

Harry A. Quigley

Publication year - 2018

Publication title -

translational vision science and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.508

H-Index - 21

ISSN - 2164-2591

DOI - 10.1167/tvst.7.6.6

Subject(s) - fasudil , rho associated protein kinase , rho kinase inhibitor , transdifferentiation , myofibroblast , sclera , proliferative vitreoretinopathy , rock1 , fibroblast , transforming growth factor , intraocular pressure , glaucoma , chemistry , medicine , pathology , endocrinology , ophthalmology , retinal detachment , kinase , retinal , protein kinase a , fibrosis , cell , biochemistry , in vitro

These findings suggest altered fibroblast activity promoted by ROCK inhibitors could modify scleral biomechanics and be relevant to glaucoma treatment.

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