Inflammatory and Angiogenic Mediators in Amniotic Fluid Are Associated With the Development of Retinopathy of Prematurity in Preterm Infants | Zendy

Se Joon Woo | Zendy; Jun Young Park | Zendy; Subeen Hong | Zendy; Yu Mi Kim | Zendy; Ye Hyon Park | Zendy; Young Eun Lee | Zendy; Kyo Hoon Park | Zendy

Open Access

Inflammatory and Angiogenic Mediators in Amniotic Fluid Are Associated With the Development of Retinopathy of Prematurity in Preterm Infants

Author(s) -

Se Joon Woo,

Jun Young Park,

Subeen Hong,

Yu Mi Kim,

Ye Hyon Park,

Young Eun Lee,

Kyo Hoon Park

Publication year - 2020

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.61.5.42

Subject(s) - retinopathy of prematurity , medicine , amniotic fluid , obstetrics , gestational age , pregnancy , fetus , biology , genetics

Elevated levels of inflammatory (IL-6 and IL-8) and angiogenic (endoglin and IGFBP-2) mediators in the AF, but not the presence of intra-amniotic infection, are independently associated with the occurrence and progression of ROP in preterm infants. These findings suggest that the pathophysiologic events that predispose preterm neonates to ROP may begin before delivery.

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