KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells | Zendy

Yuki Kanzaki | Zendy; Hirofumi Fujita | Zendy; Keita Sato | Zendy; Mio Hosokawa | Zendy; Hiroshi Matsumae | Zendy; Fumio Shiraga | Zendy; Yuki Morizane | Zendy; Hideyo Ohuchi | Zendy

Open Access

KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells

Author(s) -

Yuki Kanzaki,

Hirofumi Fujita,

Keita Sato,

Mio Hosokawa,

Hiroshi Matsumae,

Fumio Shiraga,

Yuki Morizane,

Hideyo Ohuchi

Publication year - 2020

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.61.5.38

Subject(s) - phagocytosis , biology , retinal pigment epithelium , induced pluripotent stem cell , microbiology and biotechnology , cell type , gene , immunostaining , cell , retinal , embryonic stem cell , genetics , immunology , biochemistry , immunohistochemistry

We succeeded in generating an RPE model of LCA16 using hiPSCs. We suggest that Kir7.1 is required for phagocytosis of POSs by RPE cells and that impaired phagocytosis in the absence of Kir7.1 would be involved in the retinal degeneration found in LCA16.

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