The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics | Zendy

Antoine Cherix | Zendy; Laurent Brodier | Zendy; Carole PoitryYamate | Zendy; JeanMarc Matter | Zendy; Rolf Gruetter | Zendy

Open Access

The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics

Author(s) -

Antoine Cherix,

Laurent Brodier,

Carole PoitryYamate,

JeanMarc Matter,

Rolf Gruetter

Publication year - 2020

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.61.5.3

Subject(s) - neurogenesis , retina , glycolysis , microbiology and biotechnology , biology , in ovo , retinal , morphogenesis , oxidative phosphorylation , neuroscience , biochemistry , embryo , metabolism , gene

Our results point to the vitreous as a reservoir and buffer of energy metabolites that provides trophic support to oxidative neurons, such as retinal ganglion cells, in early development. Through its control of key glycolytic regulatory enzymes, citrate, exchanged between extracellular and intracellular compartments between the retina and vitreous, is a key metabolite in the initiation of a glycolytic switch.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research