Emixustat Reduces Metabolic Demand of Dark Activity in the Retina | Zendy

Ryo Kubota | Zendy; David J. Calkins | Zendy; Susan Henry | Zendy; Robert A. Linsenmeier | Zendy

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Emixustat Reduces Metabolic Demand of Dark Activity in the Retina

Author(s) -

Ryo Kubota,

David J. Calkins,

Susan Henry,

Robert A. Linsenmeier

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-28194

Subject(s) - retina , retinal , chemistry , oxygen , biophysics , visual phototransduction , oxygen tension , adenosine triphosphate , biochemistry , biology , neuroscience , organic chemistry

In the dark, photoreceptor outer segments contain high levels of cyclic guanosine 3'-5' monophosphate (cGMP), which binds to ion channels, holding them open and allowing an influx of cations. Ion pumping activity, which balances cation influx, uses considerable amounts of adenosine triphosphate (ATP) and oxygen. Light reduces cation influx and thereby lowers metabolic demand. Blood vessels are compromised in the diabetic retina and may not be able to meet the higher metabolic demand in darkness. Emixustat is a visual cycle modulator (VCM) that reduces chromophore levels and, therefore, may mimic light conditions. We evaluated the effect of emixustat on oxygen consumption and cation influx in dark conditions.

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