The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model | Zendy

Hyun Jung Lee | Zendy; Soojung Shin | Zendy; Seul-Gi Yoon | Zendy; Eun Jung Cheon | Zendy; SoHyang Chung | Zendy

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The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model

Author(s) -

Hyun Jung Lee,

Soojung Shin,

Seul-Gi Yoon,

Eun Jung Cheon,

SoHyang Chung

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-27469

Subject(s) - chloroquine , autophagy , lacrimal gland , medicine , nod , drug , sjögren syndrome , autoimmune disease , disease , pharmacology , immunology , endocrinology , biology , pathology , biochemistry , diabetes mellitus , apoptosis , malaria

Sjögren syndrome (SS) is an autoimmune disease characterized by the inflammatory destruction of salivary and lacrimal glands (LG). Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy. The purpose of the study is to investigate the effect of CQ on the development of dry eye in NOD-LtJ mice.

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