Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts | Zendy

Koji Sugioka | Zendy; Koji Yoshida | Zendy; Junko Murakami | Zendy; Motoki Itahashi | Zendy; Hiroshi Mishima | Zendy; Teruo Nishida | Zendy; Shunji Kusaka | Zendy

Open Access

Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts

Author(s) -

Koji Sugioka,

Koji Yoshida,

Junko Murakami,

Motoki Itahashi,

Hiroshi Mishima,

Teruo Nishida,

Shunji Kusaka

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-27306

Subject(s) - plasmin , chemistry , plasminogen activator , type i collagen , collagenase , matrix metalloproteinase , microbiology and biotechnology , zymography , hydroxyproline , urokinase , epigallocatechin gallate , corneal ulceration , biochemistry , biology , cornea , endocrinology , medicine , enzyme , polyphenol , antioxidant , neuroscience

The proinflammatory cytokine interleukin (IL)-1 is implicated in corneal ulceration and promotes collagen degradation by corneal fibroblasts cultured in a three-dimensional (3D) collagen gel. Epigallocatechin-3-gallate (EGCG), the principal polyphenol in extracts of green tea, has various beneficial health effects, some of which appear to be mediated through direct or indirect inhibition of protease activity. We therefore examined the effect of EGCG on IL-1β-induced collagen degradation by corneal fibroblasts embedded in a collagen gel.

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