Rescue of Rod Synapses by Induction of Cav Alpha 1F in the Mature Cav1.4 Knock-Out Mouse Retina | Zendy

Joseph G. Laird | Zendy; Sarah H. Gardner | Zendy; Ariel J. Kopel | Zendy; Vasily Kerov | Zendy; Amy Lee | Zendy; Sheila A. Baker | Zendy

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Rescue of Rod Synapses by Induction of Ca_v Alpha 1F in the Mature Ca_v1.4 Knock-Out Mouse Retina

Author(s) -

Joseph G. Laird,

Sarah H. Gardner,

Ariel J. Kopel,

Vasily Kerov,

Amy Lee,

Sheila A. Baker

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-27226

Subject(s) - retina , alpha (finance) , neuroscience , physics , biophysics , chemistry , biology , anatomy , psychology , developmental psychology , construct validity , psychometrics

Cav1.4 is a voltage-gated calcium channel clustered at the presynaptic active zones of photoreceptors. Cav1.4 functions in communication by mediating the Ca2+ influx that triggers neurotransmitter release. It also aids in development since rod ribbon synapses do not form in Cav1.4 knock-out mice. Here we used a rescue strategy to investigate the ability of Cav1.4 to trigger synaptogenesis in both immature and mature mouse rods.

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