δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes | Zendy

Jacqueline M. Lopes de Faria | Zendy; Diego Andreazzi Duarte | Zendy; Rafael Simó | Zendy; Marta GarcíaRamírez | Zendy; Marcella Neves Dátilo | Zendy; Francieli C. Pasqualetto | Zendy; José B. Lopes de Faria | Zendy

Open Access

δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes

Author(s) -

Jacqueline M. Lopes de Faria,

Diego Andreazzi Duarte,

Rafael Simó,

Marta GarcíaRamírez,

Marcella Neves Dátilo,

Francieli C. Pasqualetto,

José B. Lopes de Faria

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-26761

Subject(s) - agonism , retinal , tight junction , diabetic retinopathy , retinopathy , diabetes mellitus , medicine , ophthalmology , microbiology and biotechnology , endocrinology , biology , politics , political science , law

Outer blood retinal barrier breakdown is a neglected feature of diabetic retinopathy (DR). We demonstrated that the agonism of the δ opioid receptor (DOR) by epicatechin preserves the tight junction proteins in ARPE-19 cells under diabetic conditions. Presently, we aimed to evaluate the possible role of the DOR on the maintenance of tight junction of RPE layer and on the early markers of experimental DR.

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