Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea | Zendy

Christian Wertheimer | Zendy; Carolin Elhardt | Zendy; Steffen M. Kaminsky | Zendy; Linh Pham | Zendy; Qing Pei | Zendy; Bryan Mendes | Zendy; Sepideh Afshar | Zendy; Irene E. Kochevar | Zendy

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Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea

Author(s) -

Christian Wertheimer,

Carolin Elhardt,

Steffen M. Kaminsky,

Linh Pham,

Qing Pei,

Bryan Mendes,

Sepideh Afshar,

Irene E. Kochevar

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.19-26604

Subject(s) - photobleaching , singlet oxygen , rose bengal , chemistry , photochemistry , sodium azide , cornea , electron transfer , oxygen , azide , irradiation , biophysics , fluorescence , biochemistry , optics , organic chemistry , nuclear physics , physics , biology

Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments.

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