Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal | Zendy

Yi Liao | Zendy; Houjian Zhang | Zendy; Danxue He | Zendy; Yan Wang | Zendy; Binxiang Cai | Zendy; Jingmeng Chen | Zendy; Jianxing Ma | Zendy; Zuguo Liu | Zendy; Yalin Wu | Zendy

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Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal

Author(s) -

Yi Liao,

Houjian Zhang,

Danxue He,

Yan Wang,

Binxiang Cai,

Jingmeng Chen,

Jianxing Ma,

Zuguo Liu,

Yalin Wu

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-26360

Subject(s) - inflammasome , retinal pigment epithelium , pyroptosis , microbiology and biotechnology , caspase 1 , biology , programmed cell death , cathepsin b , apoptosis , cathepsin d , retinal , chemistry , biochemistry , immunology , inflammation , enzyme

Visual (retinoid) cycle anomalies induce aberrant build-up of all-trans retinal (atRAL) in the retinal pigment epithelium (RPE), which is a cause of RPE atrophy in Stargardt disease type 1 and age-related macular degeneration. NLR family pyrin domain containing 3 (NLRP3) inflammasome activation is implicated in the etiology of age-related macular degeneration. Here, we elucidated the relationship between NLRP3 inflammasome activation and atRAL-induced death of RPE cells.

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