Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow | Zendy

Evan A. Thackaberry | Zendy; Yi Zhou | Zendy; Christina L. Zuch de Zafra | Zendy; Germaine Fuh | Zendy; Chingwei V. Lee | Zendy; Sarah Sanowar | Zendy; John Brady Ridgway | Zendy; Aija Kusi | Zendy; Cindy Farman | Zendy; Helen Booler | Zendy; Daniel Sheinson | Zendy; Carol A. Rasmussen | Zendy; P. Elliott Miller | Zendy; Eric Wakshull | Zendy; Minhong Yan | Zendy; Vladimir Bantseev | Zendy

Open Access

Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow

Author(s) -

Evan A. Thackaberry,

Yi Zhou,

Christina L. Zuch de Zafra,

Germaine Fuh,

Chingwei V. Lee,

Sarah Sanowar,

John Brady Ridgway,

Aija Kusi,

Cindy Farman,

Helen Booler,

Daniel Sheinson,

Carol A. Rasmussen,

P. Elliott Miller,

Eric Wakshull,

Minhong Yan,

Vladimir Bantseev

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-26349

Subject(s) - medicine , glaucoma , ophthalmology , optic nerve , ocular hypertension , intraocular pressure , retinal

Investigate a significant, dose-related increase in IOP, leading to glaucomatous damage to the neuroretina and optic nerve following intravitreal (ITV) administration of a bispecific F(ab')2 [anti-VEGF/Angiopoietins [ANGPT]F(ab')2] molecule in adult monkeys.

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