Outer Retinal Structure and Function Deficits Contribute to Circadian Disruption in Patients With Type 2 Diabetes | Zendy

Sunila Dumpala | Zendy; Andrew J. Zele | Zendy; Beatrix Feigl | Zendy

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Outer Retinal Structure and Function Deficits Contribute to Circadian Disruption in Patients With Type 2 Diabetes

Author(s) -

Sunila Dumpala,

Andrew J. Zele,

Beatrix Feigl

Publication year - 2019

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.18-26297

Subject(s) - melanopsin , circadian rhythm , pupillometry , pupillary response , medicine , ophthalmology , melatonin , diabetic retinopathy , actigraphy , retina , intrinsically photosensitive retinal ganglion cells , retinal , diabetes mellitus , pupillary light reflex , endocrinology , pupil , electroretinography , mesopic vision , psychology , neuroscience , photopic vision , photopigment , retinal ganglion cell

Light transmitted by retinal photoreceptors provides the input for circadian photoentrainment. In diabetes, there is a high prevalence of circadian and sleep disruption but the underlying causes are not well understood. Patients with diabetes can exhibit dysfunctional photoreceptors but their role in circadian health is not known. Here we quantify photoreceptor function and contributions to circadian health and sleep in patients with diabetes without diabetic retinopathy and healthy controls.

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